Membrane chromatography resolution

Tennikov, M. B., Gazdina, N., Tennikova, T. B., and Svec, F., Effect of porous structure of macroporous polymer supports on resolution in high-performance membrane chromatography of proteins, J. Chromatogr. A, 798, 55, 1998. 

MA systems can easily add a module to increase membrane capacity or resolution. Alternatively, the series addition of a traditional chromatography column for improvement of capacity or resolution is seldom practiced. Thus, membrane chromatography offers the chromatographer a new flexibility of easy expansion of inadequate systems. Alternatively, the easy connectibility also enables a simple way to couple multiple units of different chemistries for a mixed-mode separation.43 The next section describes these configurations in greater details. 

Wang PC, Gao J, and Lee CS. High-resolution chiral separation using microfluidics-based membrane chromatography. J. Chromatogr. A 2002 942 115-122. 

Capillary electrophoresis (CE) coupled to MS has the advantage of high resolution and soft ionization for biomolecules, which may be used to differentiate post-translational modifications and variants of intact proteins and oligonucleotides. Different modes of CE (capillary zone electrophoresis, capillary isoelectric focusing, capillary electrochromatography, micellar electrokinetic chromatography, nonaqueous capillary electrophoresis) to MS as well as online preconcentration techniques (transient capillary isotachophoresis, solid-phase extraction, membrane preconcentration) are used to compensate for the restricted detection sensitivity of the CE methodology [77, 78]. 

Coffman, J. L., Roper, D. K., and Lightfoot, E. N. (1994). High-resolution chromatography of proteins in short columns and adsorptive membranes. Bioseparation 4, 183-200. 

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