Melatonin transdermal delivery

Topical Formulations. Topical formulations by their very nature are usually multicomponent, and it is not surprising that neural networks have been applied to deal with this complexity. The first work was performed on hydrogel formulations containing anti-inflammatory drugs in Japan in 1997 [57], followed up by further studies in 1999 [58] and in 2001 [59]. Lipophilic semisolid emulsion systems have been studied in Slovenia [60, 61] and transdermal delivery formulations of melatonin in Florida [62]. In all cases, the superiority of neural networks over conventional statistics has been reported. 

Kandimalla KK, Kanikkannon N, Singh M. Optimization of a vehicle mixture for the transdermal delivery of melatonin using artificial neural networks and response surface method. / Controlled Release 1999 61 71-82. 

Figure 7.5 Melatonin kinetics after 10 h diurnal Cydot patch application in 12 healthy subjects. TMD =transmucosal delivery, TDD= transdermal delivery, ORAL-CR=oral controlled release delivery. (Courtesy of 3M Pharmaceuticals)...

Dubey V, Mishra D, Asthana A, Jain NK (2006) Transdermal delivery of a pineal hormone melatonin via elastic Uposomes. Biomaterials 27(18) 3491-3496... 

Hafner, A., Lovric, J., Pepic, 1., Filipovic-Grcic, J. (2011). Lecithin/ chitosan nanoparticles for transdermal delivery of melatonin, 1. MicroencapsuL 28(8), 807-815. 

Nanoparticles Melatonin Enhancement of transdermal melatonin delivery [109]... 

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