Lipophilic semisolid emulsions

Topical Formulations. Topical formulations by their very nature are usually multicomponent, and it is not surprising that neural networks have been applied to deal with this complexity. The first work was performed on hydrogel formulations containing anti-inflammatory drugs in Japan in 1997 [57], followed up by further studies in 1999 [58] and in 2001 [59]. Lipophilic semisolid emulsion systems have been studied in Slovenia [60, 61] and transdermal delivery formulations of melatonin in Florida [62]. In all cases, the superiority of neural networks over conventional statistics has been reported. 

Lipophilic semisolid emulsions have been modeled using neural networks by Gasperlin et from... 

Gasperlin, M. Tusar, L. Tusar, M. Kristi, J. Smid-Korbar, J. Lipophilic semisolid emulsion systems viscoelastic behaviour and prediction of physical stability by neural 82. network modelling. Int. J. Pharm. 1998,168, 243-254. 

Zupan, J. Kristi, J. Viscosity prediction of lipophilic semisolid emulsion systems by neural network modelling. Int. J. 83. Pharm. 2000, 196, 37-50. 

Throughout this article, other examples of ANNs used in the formulation of various dosage forms can be enumerated microemulsions [12], lipophilic semisolid emulsion [13], and hydrogels [14]. 

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