Melatonin Carbamazepine

Among the recently evaluated treatments for BZD withdrawal are anticonvulsants (carbamazepine and VPA) ( 256), melatonin (257), and ondansetron (258). Of these, odansetron had no significant effects on severity of withdrawal symptoms melatonin was found to effectively facilitate discontinuation of BZD therapy while maintaining good sleep and carbamazepine and VPA may be beneficial in the management of BZD discontinuation but not in decreasing the severity of BZD withdrawal (259, 260). 

Melatonin does not affect the serum levels of carbamazepine or its... 

Gupta M, Gupta YK, Agarwal S, Aneja S, Kalaivani M, Kohli K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy a randomized, double-blind, placebo-controlledtrial. Epilepsia (2004) 45,1636-9. 

Drug-drug interactions Melatonin is metabolized mainly by CYPIA, but CYP2C19 is also involved to a lesser extent [27 ]. Melatonin concentrations can be increased by dmetidine, quinolones, and estrogens. They are reduced by carbamazepine and cigarette smoking. 

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