Melanophore-stimulating hormones

BM Iselin, R Schwyzer. Synthese of peptide intermediates for the construction of 3-melanophore-stimulating hormone (P-MSH) of beef. I. Protected peptide sequences 1-6 and 1-7. [imide by saponification of ROCO-Asp(OMe)-] Helv Chim Acta 45, 1499, 1962. 

The presence of melanophore-stimulating hormone (MSH) in the pituitary gland of newborn children and adults was first demonstrated by Zondek and Krohn (1932). Quantitative determinations of the MSH concentration of the human hypophysis were made by Jores and Glogner (1933) through analyses of 62 samples obtained from subjects ranging in age between 11 and 90 years the frog procedure was used for the activity... 

In addition, both ACTH and MSH stimulate lipolysis in rabbit adipose tissue. That the melanophore stimulating activity associated with purified ACTH is intrinsic to the hormone and not due to contamination with the melanotropins, was conclusively demonstrated by the synthesis of a nonadecapeptide corresponding to the first 19 residues of ACTH ( ). This synthetic peptide stimulated steroidogenesis in the adrenal gland and also elicited melanin dispersion. 

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