MEISs isomerization

In the works devoted to MEISs isomerization became a "through" example for explanation of their specific features and efficiency. The example is simple and very obvious, since the isomerization reaction at any mechanism is described by the same material balance because of invariable amounts of substances and elements. This fact essentially facilitates both analytical and graphical interpretations. 

Graphical interpretation of MEIS first will be given for a parametric model of elementary reaction of isomerization. Let us suppose that the reaction proceeds with constant T and P, y = (1,0,0), the maximum value of the third isomer is found and MEIS has the form find... 

Lindlar s catalyst into the cis double bond that was subsequently photochemically isomerized to the tram double bond with phenyldisulfide [40], Final methylation with -BuLi/MeI and hydrolysis of the orthoester group resulted in the desired (4 , 75)-(-)-7-methoxy-4-tetradecenoic acid (11) as shown in Fig. (15). Therefore, the key synthetic step for the introduction of the optically active methoxy functionality was the ring opening of an optically active oxirane with a lithioalkyne [40]. 

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