Mega-insolubility

QSAR (quantitative structure activity relationship) assessment involves an elegant comparison of structural elements within known substances with similar elements in the substance under evaluation, and predicts with fair success in most substances their toxicological/ecotoxicological profile. Where QSAR can fail, however, is that it does not take into consideration the mega-insolubility in HPPs referred to in Sec. 24.3.1 above, and assumes that the pigment is always bio-avadable, which is not the case. 

Carbohydrase (Bacillus subtilis containing a Bacillus mega-terium a-amylase gene) Produced as an off white to brown, amorphous powder or liquid by controlled fermentation using the modified Bacillus subtilis. Soluble in water (the solution is usually light yellow to dark brown), but practically insoluble in alcohol, in chloroform, and in ether. Major active principle a-amylase. Typical applications used in the preparation of starch syrups, alcohol, beer, and dextrose. 

Gamma Radiation 1 mega rad 28 7 Becomes insoluble in tetralin 115.4 120 Marlex Phillips... 

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