MEF2-interaction transcription repressor

HDAC9 is the predominant member of the class II HDAC family expressed in heart (Zhang et al, 2002). Its major product was shown to encode the splice variant MEF2-interacting transcription repressor/histone deacetylase-related protein (MITRIHDRP), which lacks the enzymatic domain but forms complexes with both HDACI and HDAC3 (Zhou et al, 2000 Zhou et al, 2001) and has been recently implicated in skeletal muscle chromatin acetylation and gene expression under motor innervation control (Mejat et al, 2005). 

Zhang CL et al (2001) Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem 276(1 ) 35-39... 

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