Meerwein-Ponndorf-Verley Reduction, Oppenauer Oxidation, and Related Reactions

Meerwein-Ponndorf-Verley Reduction, Oppenauer Oxidation, and Related Reactions [Pg.273]

Meerwein-Ponndorf-Verley (MPV) reduction is one of the most popular synthetic reactions with Al(Oi-Pr)3 [72, 73]. Since this reaction is reversible, retro reaction, which is known as Oppenauer oxidation, is also used [74, 75]. [Pg.273]

Recently, Maruoka and coworkers reported aluminum mononuclear complexes [Pg.275]

In the presence of achiral or racemic aluminum complexes, enantioselective hydride transfer of chiral secondary alcohols to carbonyl compounds was well [Pg.276]

R Time Yieldof79 Method Time Yield of 80 eeof80 [Pg.278]

The Meerwein-Ponndorf-Verley reduction of aldehydes and ketones and its reverse, the Oppenauer oxidation of alcohols, are hydrogen-transfer reactions that can be performed under mild conditions and without the risk of reducing or oxidizing other functional groups [1]. The hydrogen donors are easily oxidizable secondary alcohols (e. g. i-PrOH) and the oxidants are simple ketones (e. g. cyclohexanone). Industrial applications of the MPVO reactions are found in the fragrance and pharmaceutical industries, for example. [Pg.438]

This chapter presents a comprehensive overview of heterogeneously catalyzed MPVO reactions. It includes, apart from the use of various metal oxides, the more recent application of chemically anchored co-ordination compounds, hydro-talcites, mesoporous materials, and zeolites as recyclable solid catalysts. Some remarkable examples of shape-selective conversions resulting in high stereoselectivities illustrate the progress made in this field. [Pg.439]