Medicines chelating agents

Use Insect repellent, cosmetics, vehicle and solvent in printing inks, medicine, chelating agent for boric acid. 

Pandurangi, R.S. et al. (1997a) Recent trends in the evaluation of photochemical insertion characteristics of heterobifuncdonal perfluoroaryl azide chelating agents Biochemical implications in nuclear medicine. Photochem. Photobiol. 65(2), 208-221. 

Chelating agents play a useful role in medicine, for example in the removal of toxic heavy metals from the body, but they are mostly acyclic compounds and there are few heterocyclic... 

Interest in the coupling of polyaminopolycarboxylic acids to macromolecules for use in nuclear medicine resulted in the synthesis of l-(p-aminophenyl)-ethylenediaminetet-raacetic acid (10, n = 0, R=NH2, pAPhEDTA). Since its first synthesis there have been improvements in its synthesis105 as well as the synthesis of related chelating agents (10, n = 2)106, (ll)107 and (12)108. In a search for a lipophilic chelator which could be incorporated into the lipid phase of liposomes, Bard et al.109 synthesized 3-cholesteryl 6-[N -iminobis(ethylenenitrilo)-tetraacetic acidjhexylether (13). 

Polyaminopolyphosphonic acids have attracted intermittent interest since the early applications of chelating agents in medicine. First synthesized 30 years ago, ethyl-enediaminetetraphosphonic acid (EDTMP) has only recently been examined for ability to inhibit dental calculus and caries in dogs and rats. 

A series of thioethercarboxylic acids (44, n = 1,2, 3 45) have been synthesized by Jones and his colleagues332,333. These chelating agents have been shown to have a pronounced protective action against methylmercury in mice. These chemicals still await screening in nuclear medicine. 

Radiolabeled albumin is a convenient radiopharmaceutical for several nuclear medicine procedures (20). In the past, we have attached bifunctional chelating agents to albumin by diazonium coupling (21,22). Techniques were developed to specifically radiolabel the product chelat-... 

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