Medicinal chemistry profiling experiments

The idea that a small molecule, active with a particular target protein, is very likely to be active also with a sequence-related protein is by no means new. Over several decades medicinal chemists have acquired valuable experience as to how to systematically explore chemistry space around a given lead structure, how to establish structure-activity relationships, and how to use such knowledge for refining the selectivity profile of the drug candidate. Often, selectivity with a related protein can be achieved by relatively small modifications to the original small molecule s structure. 

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