Medical applications pharmacokinetics

Chapter 9 shows the importance of PLC in the critical field of medical research, with representative examples of the applications to amino acids, carbohydrates, lipids, and pharmacokinetic studies. 

The increasing use of stimulants in the United States to treat attention deficit hyperactivity disorder (ADHD) has aroused parental concern and compelled both medical professionals and the media to question the safety and efficacy of this type of treatment. Because ADHD is among the most common reasons for seeking mental health services for children, these questions are more pertinent than ever. This chapter will examine the history of stimulant use, the mechanism of action, pharmacokinetics, side effects, and issues related to their clinical use in children and adolescents. More detailed information on clinical applications is provided in Section III. 

One of the major difficulties facing successful BNCT is the paucity of in-vivo pharmacokinetics data. Standard analytical techniques are simply not applicable to the in vivo detection of boron. To solve this problem, PET 4 and MRI5 procedures have been developed in our laboratories and the PET technique is now being used in BNCT treatment planning. In feet, a fluorine-18 analogue of BPA, 2, has been used in eight patients at University of Tennessee Medical Center to study the pre- and post-BNCT status of cancer patients.4 These patients underwent BNCT treatment of their brain tumors at Brookhaven National Laboratory and at the Massachusetts Institute of Technology (in collaboration with Harvard Medical School). 

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