Meconopsis napaulensis

The aforementioned eight bases have already been reviewed in relevant sections of Vols. 12 and 17 of this treatise. However, only a brief reference has been made in Vol. 17 to amurensinine iV-metho salt (31). Originally isolated as an unidentified quaternary base from Meconopsis napaulensis (79), it was later reisolated from various species of Meconopsis and shown to be the quaternary analog of (—)-amurensinine (25) by direct comparison with the A -metho salt prepared from authentic (—)-amurensinine (80). It should be mentioned that ( )-amurensinine A7-metho salt had been previously prepared through total synthesis (81). Two new tertiary bases have been isolated since the previous review by Santavy (5) (—)-thalidine (21) and (-)-thalidicine (23). 

Formerly, rhoeadine and papaverrubine alkaloids were known to occur only in the plants of the genus Papaver. Recently, Slavik et al. have shown that rhoeadine and papaverrubine E are present in Bocconia frutescens and papaverrubine D in Meconopsis betonicifolia, M. horridula, M. napaulensis, M. paniculata, M. robusta, M. rudis, and M. sinuata (33, 50). The genus Meconopsis is botanically closely related to the genus Papaver, a relation thus confirmed chemotaxonomically (see structures 152-154 in Table V). 

Amurensinine methohydroxide Meconopsis horridula, M. napaulensis, M. rudis... 

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