Mechano-sensitive channels

Perozo E, Kloda A, Cortes DM, Martinac B. Physical principles underlying the transduction of bilayer deformation forces during mechano-sensitive channel gating. Nature Struct. Biol. 

To trust only on mechanical instability by accumulation on a desired spot for the release of pay-load from vesicles is an imperfection of the system. By the incorporation of channel proteins in the bilayer of vesicles that can open or close upon a variety of signals smart release of encapsulated substances is brought closer. Especially the modified mechano-sensitive channel protein MscL " from Lactococcus lactis can be remotely controlled. The MscL can be modified fo be responsive to light or for... 

Sadoshima J, Takahashi T, Jahn L, Izumo S. 1992. Roles of mechano-sensitive ion channels, cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac myocytes. Proc Natl Acad Sci USA. 89 9905-9. 

Davidson, R.M., Tatakis, D.W. and Auerbach, A.L. (1990) Multiple forms of mechano-sensitive ion channels in osteoblast-like cells. European Journal of Physiology 416 646-51... 

The human inner ear is embedded in the temporal bone and houses the sensory epithelia of the cochlea and vestibular apparatus (Fig. 1). The sensory epithelia contain hair cells which transduce the stimulus of sound or motion into nerve impulses. Hair cells are equipped with an apical mechano-sensitive apparatus made up by three rows of actin-containing stereocilia of increasing length. Displacement of the stereocilia towards the longest row opens (gates) mechano-electrical transduction channels, whereas deflection into the opposing direction closes the channels [12],... 

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