Mechanistic Studies on Chiral Discrimination

Extensive studies on the resolving power of cinchona 9-O-carbamate CSPs allowed to identify a set of critical structural parameters influencing the enantioseparation 

The major factors controlling the performance of cinchona carbamate CSPs are listed as follows  

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An understanding of the recognition of chirality at a molecular level has become of interest in many fields of chemistry and biology. In the past decade, many attempts to clarify the mechanism of chiral recognition on CSPs for liquid chromatography have been made by means of chromatography, NMR spectroscopy,199 202 X-ray analysis, and computational methods.203 - 206 The successful studies have been mostly carried out for the small-molecule CSPs, especially cyclodextrin-based CSPs and Pirkle-type (brush-type) CSPs. In contrast, only a few mechanistic studies on chiral discrimination at the molecular... 

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