Mechanistic Process Modeling and Simulation

There has been a substantial effort to model the kinetics of enzymatic hydrolysis of cellulose and (pretreated) lignocellulosic substrates. Bansal et al. (2009) provide a comprehensive review of many of the models that have been developed. Most of these models are strictly empirical or based on highly simplified Michaelis-Menten concepts. Unfortunately, the assumptions commonly used with Michaelis-Menten kinetics models, namely, that reaction takes place in solution and there is a single 

FIGURE 4 J Qualitative comparison of mechanistic model predictions (top row, from Griggs et al. (2012b)) with experimental results (bottom row, from Srisodsuk et al. (1998)) for the changing DP distribution of cellulose during enzymatic hydrolysis by EG, and CBH,. The left column compares resnlts for bacterial microcrystalline cellulose (BMCC) with a relatively low initial DP, and the right column compares results for cotton linter with a relatively high initial DP. For a color version, see the color plate section.) 

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Heat and Mass Transport Mechanistic Process Modeling and Simulation Considerations for Process Integration and Economic Viability... 

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