Mechanism of Trogers Base Formation

Over the past few years, there has been a rapid increase in the application of on-line API-MS monitoring techniques to the study of organic reaction mechanisms, mainly to intercept for the first time reactive intermediates from these reactions. The ability to isolate ions direct from crude reaction mixtures has a variety of outstanding features and advantages that allow new applications of transient species in mechanistic chemistry. Undoubtedly, API-MS is now an important tool for future studies of labile and sensitive intermediaries in solution, with no need for prior purification or isolation for further characterization of active species, intermediates of reactions, and products due to on-line purifications. Such new MS techniques are also 

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