Mechanical, pharmacological approaches, separation

Acute infarct artery PCI was demonstrated initially to be feasible in conjunction with intracoronary thrombolysis in a small registry study reported in 1982 (43). The approach evolved quickly to one in which the intracoronary thrombolysis component was abandoned. The separation of mechanical and pharmacological approaches was reinforced by results in a small (56-patient), but very influential, randomized trial comparing primary PCI with administration of intracoronary streptokinase in 1986 (44). Primary PCI led to greater recovery of left ventricular function. Results from another relatively small, randomized trial (n = 142) were concordant. They demonstrated greater recovery of left ventricular function with primary PCI compared with intravenous streptokinase (45). The Primary Angioplasty in Myocardial Infarction... 

Thus it seems obviously that the analysis of hydrophobic properties of substances of natural origin is of fundamental importance in several respects, namely with the view of development of a wider application of the QSAR approach in molecular pharmacology and biochemistry, for a more complete and better understanding of the mechanisms of the effects of drugs and natural compounds in biological systems, for development of the preparative separation techniques based on the differences in the hydrophobic properties of biological materials 5), etc. 

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