Measurement using Ellman modification with

Historically, the inhibition of BuChE in plasma has been used to monitor exposure to nerve agents using the classical Ellman colorimetric method (Ellman et al, 1961), or modifications thereof (Woreketal., 1999). This method is used routinely in occupational health monitoring, and could be used to rapidly screen casualties. Its disadvantages are that detection of low-level exposure requires previous baseline measurements, and the assay is non-specific with regard to the inhibitor. 

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