Mean duration rate

A particular problem with all of these comparisons is that there is no consistency about what constitutes an accident and it should be remembered that this was one of the problems with any comparison of incidence and frequency rates. One way of improving comparisons is to calculate a rate which takes into accoxmt the severity of the accidents, i.e. the number of days lost per accident, to give the mean duration rate ... 

This mean duration rate can be used in trend analysis in the same way as other rates. A disadvantage of it is that it can give a misleading picture since it can show a decrease when the numbers of days lost is increasing, i.e. more accidents but fewer days lost per accident. 

Using the cell-attached patch clamp technique on frog muscle fibers (79), one can observe only two conditions the open, conducting state of the receptor and a nonconducting state of unknown identity. The transitions behave according to stochastic principles the lifetimes of any particular condition are distributed exponentially. The open state has a mean duration that is the inverse of the rate of channel closing. Because channel open time depends only upon a conformational shift, agonist concentration does not influence the parameter. It is, however, influenced... 

The primary characteristic of a sequential blocker, as observed with the patch clamp technique, is that the reciprocal of the mean duration of the lifetime equals the normal channel closing rate plus the rate constant of channel blockade times the drug concentration. Therefore, increasing the drug concentration shortens the mean channel open time. 

Progesterone administration induces remissions in approximately one-third of patients with metastatic endometrial cancer. The mean duration of response is 27 months. Almost 60% of endometrial adenocarcinomas contain progesterone receptors. Preliminary data show a correlation between progesterone receptor status and response rates in this disease. The mechanism of the effect of progesterone on endometrial cancer is not known. 

In a retrospective case analysis, fluoxetine (20 to 80 mg daily) and paroxetine (20 to 40 mg daily) were found to be effective in approximately one-quarter of adults (mean age, 39 years) with intellectual disability and autistic traits (Branford et al., 1998). The sample consisted of all intellectually disabled subjects who had been treated with a SSRI over a 5-year period within a health-care service in Great Britain. The mean duration of treatment was 13 months. Target symptoms were perseverative behaviors, aggression, and self-injurious behavior. Six of 25 subjects treated with fluoxetine and 3 of 12 subjects given paroxetine were rated as much improved or very much improved on the CGI. 

We can estimate the number of kinetic events that are effectively rate-limiting in any given process by quantif3ung the degree to which the distribution of its duration is peaked. The dimensionless ratio of the mean duration squared over the variance, nmin = (i) y/ a quantity related to... 

Mucormycosis has an exceedingly high mortality rate in immunocompromised patients. In five phase I and phase II studies of ABCD, 21 patients were given ABCD (mean dose 4.8 mg/kg per infusion for a mean duration of 37 days) on the basis of pre-existing renal insufficiency, nephrotoxicity during amphotericin B therapy, or refractory infections (24). Of 20 evaluable patients, 12 responded to ABCD, and there was no renal or hepatic toxicity. However, a previous randomized, comparative trial showed an at least similar if not increased frequency... 

The results of a randomized, double-blind, multicenter comparison of liposomal amphotericin (3.0 mg/kg/ day) with conventional amphotericin deoxycholate (0.6 mg/kg/day) for empirical antifungal therapy in patients with persistent fever and neutropenia have been reported (47). The mean duration of therapy was 10.8 days for liposomal amphotericin (343 patients) and 10.3 days for amphotericin deoxycholate (344 patients). While the composite rates of successful treatment were similar (50% for liposomal amphotericin and 49% for amphotericin deoxycholate), significantly fewer of the patients who received the liposomal preparation had... 

The mean duration of use of the creams before presentation with leg edema, was 13 months. The remission rate was 50% in those with minimal change... 

The mean age of onset of SAD is during the mid-teens. Rates of SAD are shghtly higher among women than men and more frequent in younger cohorts. It is a chronic disorder with a mean duration of 20 years. ... 

As a new platform alternative to CHO and NSO, which supports the production of fully human proteins, they describe the evaluation of human designer cell lines of various tissues created directly from primary cells. The hybridoma was shown to secrete the antibody in a stable manner at a rate of 45 pg (cell X day)over a period of 2 years. This is in striking contrast to the majority of heterohybridomas, which tend to quickly lose human chromosomes, resulting in unstable immunoglobulin expression. Moreover, expression was preserved when the cell line was cultivated in high-density fermentation and remained stable in five independent fermenter runs which had a mean duration of 66 days. Expression did not decrease below 30 pg (cellxday) when the medium was... 

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