MDR1 glycoprotein

D. D. Breimer. Specificity of doxorubicin versus rhodamine-123 in assessing P- glycoprotein functionality in the LLC-PK1, LLC-PK1 MDR1 and Caco-2 cell lines, Ear. J. Pharm. Sci. 2000, 11, 207-214... 

Y., Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein, Pharm. Res. 2001, 38, 1660-1668. 

Hooiveld, G. J., Heegsma, J., van Monteoort, J. E., Jansen, P. L., Meijer, D. K., Muller, M., Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdrlb P-glycoproteins,... 

Fig. 8.4 P-glycoprotein function in CD56+ natural killer cells of healthy volunteers according to MDR7 genotype at position 3435. Panel A Rhodamine fluorescence of CD56+ natural killer cells in two healthy individuals with different MDR1 genotypes in exon 26 (position 3435) after an efflux period of lOmin (gray line) compared to control cells (i.e., fluorescence of cells from the same individuals incubated for lOmin...

Rao W, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC et al. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidmg resistance-associated protein contribute to the blood-cerebrospinalfluid drug-permeability barrier. Proc Natl Acad Sci USA 1999 96(7) 3900-3905. 

Hitzl M, Drescher S, van der KH, SCHAFFELER E, FlSCHER J, SCHWAB M et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rho-damine 123 from CD56+ natural killer cells. Pharmacogenetics 2001 11 (4) 293— 298. 

Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V. The MDR1 gene, responsible for multidrug resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 1986 141 956-962. 

Van Helvoort, A., Smith, A. J., Sprang, H. et al. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87 507-17,1996. 

Drescher, S., Schaeffeler, E., Hitzl, M., Hofmann, U., Schwab, M., Brinkmann, U., Eichelbaum, M. and Fromm, M.F. (2002) MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. British Journal of Clinical Pharmacology, 53, 526-534. 

Takano, A., Kusuhara, H., Suhara, T., Ieiri, I Morimoto,T., Lee, Y.J., Maeda, J., Ikoma, Y., Ito, H., Suzuki, K. and Sugiyama, Y. (2006) Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using HC-verapamil. Journal of Nuclear Medicine, 47, 1427-1433. 

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