MDDSP

Major depressive disorder with seasonal pattern (MDDSP)... 

Supposed mechanism of action of iight therapy in major depressive disorder as part of MDDSP... 

MDDSP Major depressive disorder with seasonai pattern... 

Major depressive disorder with seasonal pattern (MDDSP) is characterized, clinically, by a depressed mood that occurs at the same time each year, virtually every year since the disorder was first experienced. These depressive states (usually modest) are often termed winter depression since they worsen as the duration of light hours is reduced during the year. The prevalence of MDDSP is estimated to be around 5% in the USA and women are affected five times more than men. As the population is located further from the equator, more people are affected. 

In healthy, euthymic subjects, the ratio of light to dark hours triggers the SCN to induce certain activities, including sleep, hormone secretion, and the secretion of melatonin (which may only serve as a marker associated with changes related to MDDSP) via stimulating the pineal gland. 

For MDD with seasonal pattern (MDDSP), bright-light therapy is the first-line treatment. Fiuoxetine and moclobemide are second-line treatments. Bupropion, citalopram, and tranylcypromine are third-line treatments. 

CBT Cognitive-behavioral therapy MDDSP MDD with seasonal pattern... 

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