MCS Mechanistic Considerations

MCS affects multiple, often unpredictable and seemingly unrelated, body sites. Different explanations have been proposed to explain this phenomenon. These are discussed here under the headings of the researchers who are their primary proponents William J. Rea, Iris R. Bell, and Martin L. Pall. 

Rea instructs that several principles must be considered to demonstrate the influence of environmental chemicals on chemical sensitivity. These 

Total body load. Total body load (burden) is the total pollutant load from whatever source that the patient carries. This can include organic chemicals, heavy metals, and other inorganics, as well as biological (bacteria, viruses, parasites, molds, and food). 

Adaptation. Adaptation addresses the body s ability to increase body load without apparent symptoms, despite the fact that 

Bipolarity. Following toxic exposure, the body develops a bipolar response of a stimulatory phase followed by a depressive phase, with the induction of immune and enzymatic detoxification systems. If the toxic insult is great enough, the induced immune and enzyme detoxification systems are depleted or depressed by overutilization and overstimulation. Bipolarity helps explain why symptoms may not be obviously related to exposures, but ensue following later exposures. 

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