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McMurry olefination intramolecular

Then Li et al. reported on a concise total synthesis of ( )-sarcophytol A (3) from the derivative of , -farnesol (91) by a low-valent titanium-mediated intramolecular McMurry olefination strategy (Scheme 6-4). ... [Pg.268]

The next synthesis, due to McMurry and Isser (22), is outlined in Chart 2. The key-intermediate is the keto epoxide (12) which was elaborated from the same Wieland-Miescher ketone (6) used by Corey, by a fivestep sequence of reactions. The keto epoxide readily underwent intramolecular alkylation to the tricyclic ketol (13). Dibromocarbene addition to the olefin derived from (13) followed by silver ion assisted solvolytic... [Pg.54]

See other pages where McMurry olefination intramolecular is mentioned: [Pg.262]    [Pg.17]    [Pg.286]    [Pg.276]    [Pg.277]    [Pg.176]    [Pg.66]    [Pg.155]    [Pg.1860]    [Pg.96]    [Pg.224]   
See also in sourсe #XX -- [ Pg.1194 ]



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Olefination intramolecular

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