Maze learning, changes caused

Other intermediate-duration oral studies in rats evaluated effects of aluminum on brain chemistry as well as neurobehavioral performance. Rats that consumed 51 mg Al/kg/day as aluminum chloride in drinking water for 180 days had alterations in behavior (reduced spontaneous locomotor activity, impaired learning, extinction and relearning of an active avoidance task, impaired maze relearning ability) and brain chemistry (increased lipid peroxidation, decreased activity of Na+-, K+-, and Mg2+-ATPases) (Lai et al. 1993). Ingestion of 490 mg Al/kg/day as aluminum sulfate in drinking water for 4-12 weeks caused reduced retention of a learned passive avoidance task and changes in brain chemistry (e.g., increased cyclic adenosine monophosphate levels, decreased concentrations of MAP-2 and other structural... 

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