Maumee Process

An alternative method involves a refined version of the Maumee process. Methyl anthranilate is initially diazotized to form 2-carbomethoxybenzenediazonium chloride sulfonation followed by oxidation then yields 2-carbomethoxybenzenesul-fonyl chloride. Amidation of this material, followed by acidification, forms insoluble acid saccharin. 

Matzke technique, 72 10 Maule color reaction, 75 7 Maumee saccharin process, 24 235 Mauritius hemp, 77 296 Mavik, molecular formula and structure, 5 151t... 

A number of methods are available for the synthesis of saccharin. For many years, the most popular process was one developed by the Maumee Chemical Company of Toledo, Ohio, in 1950. This method begins with anthranilic acid (oaminobenzoic acid C6H4(NH2)C00H), which is treated successively with nitrous acid (HN02), sulfur dioxide (S02), chlorine (Cl2), and ammonia (NH3) to obtain saccharin. Another process discovered in 1968 starts with o-toluene, which is then treated with sulfur dioxide and ammonia to obtain saccharin. 

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