Mattucinol-7-<3- 4",6"-0- aspartic protease

A number of plant natural products have been isolated that inhibit an aspartic protease secreted by Candida albicans [35, 36], the most potent of which (IC50 values 8-14 pM) are the phenolics ellagic acid [35] and mattucinol-7-0-[4",6"-0-(5)-hexahydroxydiphenoyl]-P-glucopyranoside [35] and the triterpene betulinic acid [36] (Table 1). A macromolecule from Anchusa is a potent inhibitor of pepsin (K 20 nM) [37] (Table 1). 

Mattucinol-7-0-[4",6"-0-(S)-hexahydroxy-diphenoyl]-P-D-glucopyranoside (polyphenol glycoside) Miconia myriantha (Melastomataceae) Candida albicans secreted aspartic protease (8 pM) Pepsin (67 pM) [35]... 

---

See also in sourсe #XX -- [ ]

---