Matrix-assisted laser solvent-free preparation

Matrix assisted laser desorption ionisation (MALDI) is an important technique for characterisation and fingerprinting of large molecules. However, solvents used at sample preparation have a negative effect on the quahty of the fingerprint. Work is therefore performed on development of solvent free sample preparation methods for characterisation of synthetic polymers [61]. 

Trimpin, S., Rouhanipour, A., Az, R., Rader, H.J., and Mullen, K. (2001) New aspects in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry a universal solvent-free sample preparation. 

Falkenhagen, J. Weidner, S. M. Detection limits of matrix-assisted laser desorp-tion/ionisation mass spectrometry coupled to chromatography—A new application of solvent-free sample preparation. Rapid Commun. Mass Spectrom. 2005, 19, 3724-3730. 

Trimpin, S. Rouhanipour, A. Az, R. Rader, H.J. Mullen, K. New Aspects in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry a Universal Solvent-Free Sample Preparation. Rapid Commun. Mass Spectrom. 2001,15,1364-1373. 

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