Mathematical Modeling of Gas-Solid Chromatography

As was evidenced above, the attempts to derive the zone profiles by solution of the appropriate differential equations meet severe difficulties. In such situations, it seems reasonable to trace the influence of various variables, as well as of the experimental conditions, by computer simulation of the histories of single molecular entities migrating down the column. 

Reproduced from Journal of Radioanalytical and Nuclear Chemistry Articles, 204(1), Zvara I, Problems in thermochromatographic separation of radioelements, 123-134, 1996, with permission from Springer. 

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Chapter 4 starts with some basic equations, which relate the molecular-kinetic picture of gas-solid chromatography and the experimental data. Next come some common mathematical properties of the chromatographic peak profiles. The existing attempts to find analytical formulae for the shapes of TC peaks are subject to analysis. A mathematical model of migration of molecules down the column and its Monte Carlo realization are discussed. The zone position and profile in vacuum thermochromatography are treated as chromatographic, diffusional and simulation problems. 

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