Mass spectrometry rationale

An intriguing application of this hypothesis may have been observed in the mass spectrometric behavior of MTO.86 Loss of H2 and CO from the parent ion were the major processes observed in both metastable ion and collisional activation mass spectrometry. Both were viewed as unusual the latter, in particular, required a rationale for forming a C—O bond. The authors proposed migration of carbon to oxygen in the parent ion to form a methoxyrhenium complex of the same mass, followed by sequential back migration of the hydrogens ... 

Hydrogen Exchange Mass Spectrometry of Proteins 14.1.1 Rationale for Epitope Mapping... 

A few computational chemists argue defensively that it is inappropriate to ask what produas have come from computational chemistry. Their rationale is that it is a research tool, and since no one asks what commercial chemical products can be directly attributed to other research tools, such as mass spectrometry, nuclear magnetic resonance spectroscopy, or X-ray crystallography, why ask what products can be directly attributed to computational chemistry Nonetheless, the literature does document cases in which the computer has provided assistance in designing compounds that became commercial products. 

Bencsura et al. [12] in 1992 produced the most recent experimental data on the reaction kinetics of the propyl radical, based on previous work. Radicals were produced by pulsed laser photolysis and their unimolecular decay subsequently studied by photoionization mass spectrometry. Tsang [13] in 1988 produced a compilation of revised and evaluated data on the kinetics of reactions involving propane and the propyl radical, among other species. The general mechanism for the decomposition of propane was initially determined by Papic and Laidler [14, 15] who experimentally identified most of the products which are consistently predicted in the mechanism proposed in this paper. We followed their rationale for the development of our own model. 

One of the most fascinating fields of instrumental development in mass spectrometry (MS) is hyphenation the on-line coupling of various techniques to MS. Apart from the obvious combinations of straightforward coupling of gas chromatography (GC) or liquid chromatography (LC) to MS, a wide variety of other combinations has been described. This contribution pays attention to the rationale of hyphenated techniques and briefly indicates a number of typical applications. 

Since 1990, EPO has been prohibited by the IOC and WADA, and a study published by Videman in 2000 stressed the rationale a considerable increase of total hemoglobin mass in elite cross country skiers has been measured since recombinant EPO has become commercially available. Hence, the search for an adequate assay to determine the misuse of EPO in sports has been an important item of anti-doping research. With regard to mass spectrometry, research activities have been limited primarily due to the complexity and nearly identical... 

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