Mass limit of detection. MLOD

The limit of detection (LOD) of a system can be defined in two ways the concentration limit of detection (CLOD) and the mass limit of detection (MLOD). The CLOD of a typical peptide is about 1 jLg/mL using absorbance detection at 200 nm. If 10 nL are injected, this translates to an MLOD of 10 pg at three times the baseline noise. The MLOD illustrates the measuring capability of the instrument. The more important parameter is the CLOD, which relates to the sample itself. The CLOD for HPCE is relatively poor, whereas the MLOD is quite good, especially when compared to HPLC. In HPLC, the injection size can be 1000 times greater compared to HPCE. 

IS(TD) Internal standardisation (calibration) mLOD Mass limit of detection... 

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