Marrow, viii

Chuah, M. K., Van Damme, A., Zwinnen, H., Goovaerts, I., Vanslembrouck, V., Collen, D. and Vandendriessche, T. (2000). Long-term persistence of human bone marrow stromal cells transduced with factor VUI-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice. Hum. Gene Ther. 11, 729-738. 

Rapidly proliferating normal cells are more sensitive to cytotoxic drugs. Bone marrow suppression [ often determines the upper limit of tolerable chemotherapy. Table Vll-l-l lists mechanisms of action, selected clinical uses, and adverse effects of major anticancer drugs. Table VIII-l-2 shows the dose- j limiting and distinctive toxidties of anticancer drugs. j... 

Chloramphenicol produces two types of bone marrow damage (l)an immediate type of reaction which is dose-dependent and causes a reversible suppression of the formations of erythrocytes, thrombocytes and granulocytes, and (2) a delayed type of reaction which occurs less frequently, is unrelated to dosage, and has a high mortality (SED VIII, pp. 605-608). 

Some new cases of bone marrow depression, a well-known side effect (SED VIII), have been reported (9, 10 ). In 3 cases of acute agranulocytosis (2 secondary to methi-mazole and 1 secondary to propylthiouracil)... 

This is an antifolate and a cytotoxic agent which acts by interfering with purine synthesis (SED VIII, p. 964). Its toxic effects include a depressive effect on the bone marrow, ulceration of the gastrointestinal mucosa with the production of nausea, vomiting, diarrhoea, and effects on the skin. These acute toxic effects are related to dose, to renal function and sometimes to idiosyncrasy. 

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