Marine toxins analytical detection

Saxitoxin has been labeled with fluorescamine, o-phthaldialdehyde (OPA) and dansyl chloride and detection limits as low as 0.1 attomole were reported for the OPA derivative of saxitoxin (26). Labeling, separation, and analysis of saxitoxin was best accomplished using fluorescamine, which produces ionic derivatives that can be separated from other fluorescently labeled marine toxins, such as tetrodotoxin and microcystin. However, the precolumn labeling methods required xM concentrations of analyte, limiting the utility of the technique for trace analysis. 

Hess and Aasen (2007), and Tubaro et al (2010), and for recent analytical techniques of detection, see Krock et al (2009), Reis Costa et al (2009), and CiminieUo et al (2010). Lastly, it was shown that industrial processes decrease the marine ASP and PSP toxin content of shellfish, but less significantly for DSP toxins (Reboreda et al, 2010). 

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