Marine macrolide antitumor activity

Spongistatins 113, also referred to as altohyrtins in the literature, are complex marine macrolides that were isolated from marine sponges (Figure 19.10) [60]. Aside from the formidable structure, interest in these compounds has been stimulated due to their potent antitumor activity. Schwenter and Vogel, who have developed a new methodology for the preparation of polypropionates based on a double [4+3] cycloaddition, saw the spongistatins as an opportunity to... 

Iwata, Y, Tanino, K., and Miyashita, M. (2005) Synthetic studies of tedanolide, a marine macrolide displaying potent antitumor activity. Stereoselective synthesis of the C(13)—C(23) segment. Org. Lett, 7, 2341-2344. 

Nishimura, S., Matsunaga, S., Yoshida, M., Nakao, Y, Hirota, H., and Fusetani, N. (2005b) Structure-activity relationship on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens. Bioorg. Med. Chem., 13, 455-462,... 

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