Maprotiline poisoning with

Park J, Proudfoot AT. Acute poisoning with maprotiline hydrochloride. BMJ 1977 1(6076) 1573. 

Knudsen K, Heath A. Effects of self poisoning with maprotiline. BMJ (Clin Res Ed) 1984 288(6417) 601-3. 

Placebo-controHed studies In a doubleblind, randomized, placebo-controlled study in 105 unconscious adults with suspected drug overdose, 73 of whom had taken benzodiazepines, flumazenil caused adverse effects in nine cases agitation (n = 3), a depressive mood (n = 3), nausea and vomiting (n = 1), shivering (n = 1), and one severe adverse reaction—a sudden fall in blood pressure in a 28-year-old woman in deep coma after combined poisoning with benzodiazepines and maprotiline [95 "]. 

Alten HE, Koppel C, Ibe K. Akute Vergiftung mit Maprotiline mit lethalem Ausgang. [Acute poisoning by maprotiline with fatal outcome.] Intensivmedizin 1980 17 71. 

One of the putative benefits of mianserin is its alleged safety in overdose, which may be related to a reduced risk of cardiovascular adverse effects and convulsions. Data from the UK Committee on Safety of Medicines suggest that mianserin accounts for 11% of reported convulsions and 5.8% of use, putting it intermediate between amitriptyline and maprotiline (15). On the other hand, in the London Poisons Unit survey, involving 84 patients who took mianserin alone (up to 1000 mg), there were no deaths and no patients with convulsions, although this could represent a frequency of up to 3.6% (12). 

---