Mappicine library fluorous mixture synthesis

Source Reproduced with permission from Zhang W., Luo, Z, Chen, C. H.-T. Curran, D. Solution-Phase Preparation of A 560-compound library of individually pure mappicine analogs by fluorous mixture synthesis, J. Am. Chem.Soc. (2002) 124, 10443-10450. Copyright (2002) American Chemical Society.)... 

The introduction of additional substituent groups in combination with the discriminating perfluoroalkyl labels during the synthetic sequence enables convenient preparation and subsequent separation of relatively large libraries. For the library of 100 mappicine derivatives outlined in Scheme 3.20, 300 reactions would be required for the conventional, sequential approach. By application of fluorous mixture synthesis this was condensed into 26 steps. In addition, four tagging and 100 detagging operations are required to obtain the full, unprotected 100-member library from unprotected starting materials. 

Zhang W et al (2002) Solution-phase preparation of a 560-compoimd library of individual pure mappicine analogues by fluorous mixture synthesis. J Am Chem Soc 124 10443-10450... 

---