Of mappicine analogues

Figure 13.1 Semi-preparative F-HPLC demixing of a seven-component mixture of mappicine analogues.

The power of FMS has been further demonstrated in the preparation of a 560-member library of mappicine analogues (see Scheme 13.13) [25], In this case, the fluorous tags encoded substrates with different substitutions rather than substrates with different... 

Also in this case, Curran and coworkers produced a library of 64 mappicine analogues by automated solution-phase combinatorial synthesis, as well as a 48-mem-ber library of mappicine ketone derivatives [88]. Furthermore, these authors were successful in building up a 115-member library of rac-homosilatecans 3-216 using different iodopyridones 3-214 and aryl isocyanides as substrates 3-215 (Scheme 3.56) [89]. 

Zhang W et al (2002) Solution-phase preparation of a 560-compoimd library of individual pure mappicine analogues by fluorous mixture synthesis. J Am Chem Soc 124 10443-10450... 

Curran and coworkers [141] developed a palladium(0)-catalysed domino process for the synthesis of the very potent anticancer natural product (S)-camptothecin (283) [142] and its analogues (Scheme 8.70). Camptothecin (283) contains an ll//-indolizino[l,2- ]quinolin-9-one skeleton, which is also found in mappicine [143] and the promising new analogue DB-67 (287) [144]. A domino-radical reaction has been used for its construction in 40-60% yield [145]. However, the product is also accessible from the isonitrile 284... 

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