MAP2 microtubule-associated protein

R.B. Vallee, M.J. Dibartolcmeis and W.E. Theurkauf A protein kinase bound to the projection portion of MAP2 (microtubule-associated protein 2) J. Cell Biol. 90 568 (1981). 

The microtubule-associated proteins MAP2 and tau both have two separate functional regions (Lewis et al., 1989). One is the microtubule-binding site, which nucleates microtubule assembly and controls the rate of elongation (by slowing the rate of assembly). The second functional domain shared by MAP2 and tau is a short C-terminal a-helical sequence that can cross-link microtubules into bundles by self-interaction. This domain has some of the properties of a leucine zipper. Likely it is responsible for the organization of microtubules into dense stable parallel arrays in axons and dendrites (Lewis et al., 1989). 

Lewis, S.A., Ivanov, I.E., Lee, G.-H., Cowan, N.J. (1989). Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau. Nature 342,498-505. 

Schanen, N.C. Landreth, G. Isolation and characterization of microtubule-associated protein 2 (MAP2) kinase from rat brain. Mol. Brain Res., 14, 43-50 (1992)... 

Taft W. C Yang K Dixon C. E Clifton G. L and Hayes R. L. (1993) Hypothermia attenuates the loss of hippocampal microtubule-associated protein 2 (MAP2) following traumatic brain injury. J. Cereb. Blood Flow Metab. 13, 796-802. 

Eischer, I., Romano-Clarke, G., and Grynspan, E, 1991. Calpain-mediated proteolysis of microtubule associated proteins MAPIB and MAP2 in developing brain, Neurochem. Res., 16, pp. 891-898. 

Caceres A, Binder LI, Payne MR, Bender P, Rebhun L, Steward O (1984) Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies. J Neurosci 4 394-410. 

Most primary tumors of the pineal gland originate from pineocytes, which represent modified neurons similar to retinal photoreceptor cells.Pineocytomas are typically positive for NSE, synaptophysin, neurofilament proteins, tan protein, and microtubule-associated protein-2 (MAP2) (Fig. 10.5). GFAP and S-100 protein are present in 75% and 83% of cases, respectively. 

MAPK is a serine/ threonine kinase that has been originally identified as a microtubule-associated protein 2 (MAP2) kinase (this is also termed "MAPK" or "MAP2 kinase") and then well recognized as a mitogen-activated protein kinase (Mailer 1990). MAPK is a component of the MAPK kinase, which consists of at least three step of phospho-dependent... 

Cytoskeletal proteins Microtubule-associated protein-2 (MAP2) MAP2 MAP2... 

This enzyme [EC 2.7.1.123], also referred to as calcium/ calmodulin-dependent protein kinase type II, and micro-tubule-associated protein MAP2 kinase, catalyzes the reaction of ATP with a protein to produce ADP and an 0-phosphoprotein. The enzyme requires calcium ions and calmodulin. Proteins that can serve as substrates include vimentin, synapsin, glycogen synthase, the myosin light-chains, and the microtubule-associated tau protein. This enzyme is distinct from myosin light-chain kinase [EC 2.7.1.117], caldesmon kinase [EC 2.7.1.120], and tau-protein kinase [EC 2.7.1.135]. 

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