Metaraminol MAOIs

Contraindications Cyclopropane or halothane anesfhesia, use of MAOIs, hypersensitivity to metaraminol... 

A very well-documented, serious, and potentially fatal interaction. Patients taking any of the MAOIs should not normally take any sympathomimetic amine with indirect activity. These include ephedrine, isometheptene mucate, mephentermine, metaraminol, phenylpropanolamine and pseudoephedrine. Direct evidence implicating methylephe-drine and pholedrine seems not to have been documented, but on the basis of their known pharmacology their concurrent use with the MAOIs should be avoided. 

Physicians should also avoid the use of indirectly-acting vasoconstrictor amines such as ephedrine, mephentermine and metaraminol for reversing hypotension during spinal anaesthesia in patients taking MAOIs or who have recently stopped these (within the previous 2 weeks). 

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