Cystic fibrosis mannitol

A modification of the test has been the use of mannitol as a control marker, which can then be administered together with the FDL, enabling the patient procedure to be completed within 1 day. Urine was collected from 2 to 8 hours and the ratio of fluorescein to mannitol recoveries calculated. A clear separation between healthy controls and children with cystic fibrosis was obtained regardless of whether or not they were on enzyme replacement therapy. ... 

Respiratory Inhaled mannitol as a dry powder has been used to treat patients with cystic fibrosis, since it increases mucociliary clearance by rehydrating the airways. In 39 children with cystic fibrosis, aged 8-18 years, a bronchial provocation... 

Minasian C, Wallis C, Metcalfe C, Bush A. Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis. Pediatr Pulmonol 2008 43(11) 1078-84. 

In addition to its use as an osmotic diuretic in cerebral oedema, mannitol is also frequently used in powdered form by inhalation to treat respiratory disorders like cystic fibrosis, asthma and bronchiectasis [SEDA-35,393],... 

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