Mammalian species interspecies scaling

Patel BA, Boudinot FD, Schinazi RF, Gallo JM, Chu CK (1990) Comparative pharmacokinetics and interspecies scaling of 3 -azido-3 -deoxythymidine (AZT) in several mammalian species. J Pharmacobiodyn 13 206-211... 

The basic assumption in interspecies scaling is that physiological variables and biochemical processes are related to the body weight of mammalian species. The use of clearance, a physiologically based parameter, may be more appropriate than half-life (a hybrid... 

The ERA summarized previous empirical attempts at interspecies comparisons, including those listed above, and discussed at length various observations and hypotheses about pharmacokinetics and pharmacodynamics that lead to an expectation of allometric scaling (ERA 1992). The ERA concluded that the empirical evidence at that time was consistent with allometric scaling such that lifetime cancer risks would be approximately equal for mammalian species when daily amounts administered are in proportion to body weight raised to any power between 2/3 and... 

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