Malonamic acid

The yields of malondiamides starting from various malonamic acids are, however, higher 11381... 

C2 Alkylation of cyanoacetates followed by hydrolysis results in C2-substituted malonamic acids suitable for incorporation at the C-terminus of PMRI-peptides. However, due to the higher acidity of the C2 protons, dialkylation at the C2 position may occur. 103 Cushman et al.Pl successfully applied this strategy for the synthesis of a terminal mMet-amide-modified bombesin derivative (Scheme 9). 

Chemical Name Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo(3.2.0)hept-6-yl)-2-phenyl-, 1-phenyl ester monosodium salt... 

Use the technique of eliminating time as a variable to determine the relationship between the concentrations of species A and B prevailing at any point in the reactor. Use this relation and the information from part (hi) to prepare a plot of the malonamic acid concentration in the effluent that would reflect the influence of a dispersion number EJuL of 0.06. 

Acoxynitrones a-Acylperoxynitriles Carbamylketeneacetals Malonamic acid esters... 

Malonamic Acid Malonic acid monoamide, malortamidic acid, carbamylacetic acid)... 

Hamper BC, Synderman DM, Owen TJ, Scales AM, Owsley DC, Kesselring AS, Chott RC. High-throughput H-1 NMR and HPLC characterization of a 96-member substituted methylene malonamic acid library. J Comb Chem 1999 1 140-150. 

Diacids.—Succinic acid derivatives can be obtained in good yields by coupling lithium a-lithiocarboxylates (or ester enolates) with lithium a-halocarboxylates, or a-halo-esters/ Carboxylic acid dianions also react with isocyanates and iso thiocyanates to give malonamic acids (13 X = O) and 3-thiomalonamic acids (13 X = S), respectively/ A route to c/5-cyclobutane-l,2-dicarboxylic acids (16), which could be of some generality, consists of photocyclization of acryl-imides (14) to maleimides (15) and hydrolysis/ Yields of (15), as judged by n.m.r. spectra, are between 45 and 82%. 

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