Malignant atrophic

Primary vasculitis of the central nervous system Takayasu s disease Buerger s disease Malignant atrophic papulosis... 

Malignant atrophic papulosis, or Dego s disease, is a very rare syndrome consisting of crops of painless pinkish papules on the trunk and limbs that heal as distinctive circular porcelain-white scars. It may be complicated by ischemic lesions in the gut, brain, spinal cord and nerve roots owing to endothelial proliferation in small arteries (Sotrel et al. 1983 Subbiah et al. 1996). 

Nevertheless, special attention is necessary for the management of patients with large (1.6- to 2.0-cm) and deeply invasive type I well-differentiated ECL tumors that tend to have a low-grade malignant behavior. This clinical profile closely matches that of the 197 chronic atrophic gastritis-associated gastric neuroendocrine tumors previously published and of the 27 similar tumors included in the series of 104 gastric carcinoids recently reported. 

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