Makinoa crispata

Makinoa crispata (Steph.) Miyake from Japan was shown by Hashimoto et al. (1989) to contain diterpene derivatives of the sort illustrated as [466-469] (see Fig. 5.7 for stractures). More recently, Liu and Wu (1997) reported the presence of the rearranged abietane-type diterpenoid derivative makanin [470] from plant material of M. crispata collected on Taiwan. Of note was the apparent absence of any of these compounds in the Japanese plants. 

Hashimoto, T., Tori, M. and Asakawa, Y. 1989. Drimane-type sesquiterpenoids from the liverwort Makinoa crispata. Phytochemistry 28 3377-3381. 

Liu, H.-J. and Wu, C.-L. 1997. A rearranged abietane-type diterpenoid from the liverwort Makinoa crispata. Phytochemistry 44 1523-1525. 

New additions to the eudesmanolide family include (610)—(635).105 154 220 222-231,247,249,276-282 examination of liverwort species continues to reveal interesting new structures such as those of (+)-p-frullanolide (636) and (+)-brothenolide (637) from Frullania brotheri283 and (+)-crispatanolide (638) from Makinoa crispata.2Si The last compound is unique in the eudesmane field having a 8-lactone attached between C-7 and C-14. 

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