Maintenance dose intravenous route

The major problem with the intravenous route in children is dosing errors. Because of the unavailability of stock solutions prepared for pediatric doses, errors in dilution of an adult stock solution have resulted in 10- to 20-fold errors in administered doses [87,88], A secondary problem is the maintenance of patent intravenous lines in infants and nonsedated children. 

Calculation of loading (Dl) and maintenance dose (Dm) for both intravenous bolus and extravascular routes. 

Dosages and routes of administration Levomethadone can be given by mouth or by intravenous, intramuscular, subcutaneous or intraspinal injection. For pain treatment, intravenous doses are between 2.5 and 5 mg and oral doses between 5 and 10 mg. For maintenance treatment in addicts, much higher oral doses up to more than 100 mg are used. 

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