Mainchain structures

B. Conversion of Cobaltacyclopentadiene-Containing Polymers into Polymers Possessing Various Mainchain Structures... 

Unconjugated 1,5- and 1,6-dienes are known to undergo intramolecular-intermolecular polymerization or cyclopolymerization to form polymers with cyclic mainchain structure >, but a very few are reported about cyc1opo1ymerization of fluoro- or perfluorodienes. Perfluorodienes with a general formula CFz=CF-(CF2)xCF=CF2 (x=1 to 4) and CFz=CFCF2CFC CF2CF=CFz are reported to be cyclopolymerized under... 

Binding to lysozyme stabilizes a conformation in site D compatible with the alternative mechanism. (i) Hg of residue D does not interact with residue E but forms a strong hydrogen bond to the mainchain 0 of residue 57, a residue involved with the unusual buried p turn in lysozyme. (ii) The value of 0 between D and E, which was -54 in the initial structure, stabilized at -62 , near the optimum of -60 for stereoelectronic assistance. 

Three-dimensional structures of four subtilisin-type enzymes, subtilisin BPN, 36373 subtilisin Carlsberg,37,383 thermitase,39,403 and proteinase K,40,413 are known, but that of aqualysin I has not yet been determined. The Ca atoms of the known structures were superimposed to obtain maximal overlap of the backbone structures, and large parts of all four structures overlap very well (Fig. 12.3) 423 On the basis of such analyses, structurally equivalent core residues (194 residues) are identified, and higher sequence identity was found to correspond to a closer overlap of mainchain atoms in the core (Table 12.1).423... 

Figure 5. X-ray crystal structure of wild type thioredoxin (A) and the calculated structure of L78K-TRX (B). Distances between mainchain amide protons are given in A.

Yang, Honig [204] PrISM Multiple structures are aligned, and the most appropriate template is used for each segment of the target to be built. Loops are built ah initio and side chains are built using the template or based on mainchain torsions and a neural network algorithm. 

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