Magnetic sector-oaTOF

The development of hybrid instruments started from magnetic sector-quadmpole hybrids, either BqQ [221,222], EBqQ, [223] or BEqQ [224-226]. Numerous other systems such as magnetic sector-QIT [227], magnetic sector-oaTOF [228,229], QITTOF [138,230,231], QqTOF [49,232-234], QqLIT [108], LITICR, andQqlCR followed (Table 4.3). 

Requires high-cost magnetic sector instruments or oaToF-MS... 

Geometries composing of an oaTOF as MS2 bear the advantage that advanced TOFs offer accurate mass measurements close the the accuracy of magnetic sector instruments. Currently, QqTOF systems can be regarded as the commercially most successful hybrid. While the linear quadrupole serves as MSI in MS/MS experiments, it is operated in RF-only mode when tandem MS is not intended, because... 

Magnetic sector instruments (Chap. 4.3) were used first to demonstrate the beneficial effects of resolution on ESI spectra of biomolecules. [96,103,104] Fourier transform ion cyclotron resonance (FT-ICR, Chap. 4.6) instruments followed. [105-107] The more recently developed orthogonal acceleration of time-of-flight (oaTOF, Chap. 4.2 and 4.7) analyzers also present an effective means to resolve all or at least most peaks. [108-110]... 

Fig. 8.2. Potentials bold lines) along different H/FD ion sources to realize full extraction voltage while delivering ions of defined kinetic energy to the analyzer. The part numbers correspond to 1 emitter, 2 counter electrode, 3 optional electrostatic lenses, 4 analyzer entrance slit, (a) Instruments with high acceleration voltage, (b) instruments with medium acceleration voltage as is often the case in magnetic sector instruments, and (c) instruments requiring slow ions, e.g., FT-ICR or oaTOF instmments.

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