Magnetic cell manipulation

Figure 30 Schematic of the UHV/antechamber/transfer chamber system for electrochemical measurements involving solid polymer electrolytes. Insert A provides an exploded view of the HOPG(bp) sample holder and Li[C/R]/PE0(LiC104) stainless steel holder (SSH) arrangement attached to both magnetically coupled manipulators. Insert B shows in detail the assembled H0PG(bp)/PE0(LiC104) cell in the UHV chamber. MCM = magnetically coupled manipulator GV = gate valve N = nipple CN = ceramic nipple SSH = stainless steel holder TMP = turbomolecular pump. (From Ref. 6.)...

An alternative to dielectrophoretic or magnetic force manipulation of microparticles in suspension is the use of acoustic standing wave forces, which also have served as the basis for particle and cell manipulation in microfluidic devices. Historical work by Kundt demonstrated early on the ability to move cork particles in a standing wave pattern. The fundamental acousto-physical principles have been well researched and described in the literature by King and Gorkov. ... 

Cell manipulation using magnetic nanowires. Journal of Applied Physics,... 

Figure 6. Merge, mix, split, and transport were the main manipulation steps used for on-chip droplet-based DNA purification. The system was able to extract genomic material from dilute raw cell samples by using the actuation of magnetic microparticles within the droplet using a matrix of coils [50],...

H. Lee, Y. Liu, R.M. Westervelt, and D. Ham IC/Microfiuidic hybrid system for magnetic manipulation of biological cells. leee Journal of Sohd-State Circuits 41, 1471-1480 (2006). 

This effect can be used to position and manipulate single cells or large viruses in solution. For other biophysical studies, individual macromolecules can be tethered to one or more latex or plastic beads and manipulated using optical tweezers. Other techniques combine similar approaches using small magnetic beads. 

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