Magnesium meta-analysis

Example 15.4 Meta-Analysis of trials of magnesium and streptokinase in acute myocardial infarction... 

Figure 15.2 Funnel plot for meta-analysis of trials of magnesium (upper diagram) and streptokinase (lower diagram) in acute myocardial infarction. (Smith and Eggar (1997). Reproduced with kind permission from The Lancet.)...

At Johns Hopkins University in Baltimore, doctors collected data from twenty trials that looked at the effects of magnesium supplementation on blood pressure. They pooled the data to form one megastudy, in what is termed a meta-analysis. In six of the studies, subjects had normal blood pressure in the others, patients were hypertensive. The data came from 1,220 men and women, and the daily dose of magnesium ranged from 10 to 40 mmol (180 to 720 mg). 

The use of intravenous magnesium sulfate also has been entertained for the prevention of ventricular fibrillation during the acute infarct period. Small trials implying effectiveness subsequently were incorporated into a meta-analysis. This meta-analysis found a... 

Homer SM. Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortaUty Meta-analysis of magnesium in acute myocardial infarction. Circulation 1992 86 774-779. 

Wu X, Wang C, Zhu J, Zhang C, Zhang Y, Gao Y. Meta-analysis of randomized controlled trials on magnesium in addition to beta-blocker for prevention of postoperative atrial arrhythmias after coronary artery bypass grafting. BMC Cardiovasc Disord 2013 3 5. 

Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure a meta-analysis. Eur J Qin Nutr 2012 66(4) 411-8. 

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