Magnesium depletion

The severity of magnesium depletion and presence of symptoms dictate the route of magnesium supplementation (Table 78-7). Intramuscular magnesium is painful and should be reserved for patients with severe hypomagnesemia and limited venous access. IV bolus injection is associated with flushing, sweating, and a sensation of warmth. 

M. Hara, S. Morozumi, K. Watanabe, Effect of a magnesium depletion on the Mg-Ni-Y aUoy hydrogen absorption properties , J. Alloys Compd. 414 (2006) 207-214. 

Electrolyte disorders In patients with hypokalemia or hypomagnesemia, toxicity may occur despite serum digoxin concentrations less than 2 ng/mL, because potassium or magnesium depletion sensitizes the myocardium to digoxin. Therefore, it is desirable to maintain normal serum potassium and magnesium concentrations in patients being treated with digoxin. 

Magnesium oxide Treatment of magnesium deficiencies or magnesium depletion. 

Magnesium sulfate Sustained ventricular arrhythmias Torsades de pointes of magnesium depletion or glycoside toxicity... 

C.V. Odvina, R.P. Mason, C.Y.C. Pak, Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium citrate, Am. J. Ther. 13 (2006) 101-108. 

Hyperoxaluria and hypomagnesiuria, which negate the beneficial effect of hypo-calciuria on new stone formation, magnesium depletion, and depletion of trace metals (copper, zinc, iron) may occur. 

Magnesium depletion is a predictable consequence of the chronic use of loop agents and occurs most often in patients with dietary magnesium deficiency. It can be reversed by administration of oral magnesium preparations. 

MAGNESIUM HORMONE REPLACEMENT THERAPY May cause magnesium depletion Mg levels tend to l during menopause. Risk-benefit ratios need to be considered on an individual basis as there are suggestions that magnesium can counteract the alleged T risk of heart attacks and strokes in patients on hormone replacement therapy Be aware... 

MAGNESIUM ORAL CONTRACEPTIVES May cause magnesium depletion Oral contraceptives tend to increase copper levels, which when high results in l magnesium levels Be aware... 

MAGNESIUM PENICILLAMINE May cause magnesium depletion Penicillamine l absorption of several minerals, including magnesium Be aware and separate the oral intake. Parenteral magnesium is unlikely to be affected... 

Shils, M. E. (1969). Experimental human magnesium depletion. Medicine 48,61-85. 

Alfrey, A. C., Miller, N. and Trow, R. (1974). Effect of age and magnesium depletion on bone magnesium pools in rats. /. CJiw. fwesf. 54, 1074-1081. 

Tudapaty 1., and Altura, B. M. (1980). Magnesium depletion produces spasms of coronary arteries Relationship to etiology of sudden death ischemic heart disease- Scj ettce 208, 198-200. 

Magnesium depletion may have a similar effect (213), but the data are not as clear-cut as those for potassium. 

Reyes AJ, Leary WP. Cardiovascular toxicity of diuretics related to magnesium depletion. Hum Toxicol 1984 3(5) 351-71. 

Gentamicin-induced magnesium depletion is most likely to occur in older patients when large doses are used over long periods of time (16). Under these circumstances, serum concentrations and urinary electrolyte losses should be monitored. 

Whang R, EUnk EB, Dyckner T, et al. Magnesium depletion as a cause of refractory potassium repletion. Arch Intern Med 1985 145 1686— 1689. 

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